GETTING MY CEESDEKKER TO WORK

Getting My ceesdekker To Work

Getting My ceesdekker To Work

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Employing single-molecule optical and AFM imaging and force-spectroscopy approaches, we find to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our investigate passions consist of:

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Dynamics of initiation, termination and reinitiation of DNA translocation through the motor protein EcoR124I

Deposition and atomic pressure microscopy of specific phthalocyanine polymers amongst nanofabricated electrodes

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SMC complexes can move physical roadblocks bigger than their ring sizing, indicating a nontopological system for DNA loop extrusion

Many associated developments followed, exactly where our group set up distinct transistor variants including solitary-electron transistors at space temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled several transistors into tiny proof-of-principle electronic circuits.

Researching DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.

‘Sure, I fully grasp individuals ended up surprised at time. At the conclusion of the nineties, when I was in my forties, I used to be Professor of Molecular Electronics and I've to admit that it had turn into a little bit bored, I didn’t discover Substantially anymore. The field went additional into the appliance facet, how you may combine nanotubes into Digital circuits.

There was just one trouble though — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at the single-molecule level, conducting polymers had been truly not this sort of wonderful conductors, which was somewhat disappointing. We Consequently broadened our perspective to test to search out extra promising molecules.

Example (four) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in grey, the rim of the pore is highlighted in pink, and also a 3D rendering on the motion of the DNA rod is exhibited.

2001, discovery of one-electron transistors at home temperature dependant on nanotubes; realization of first logic circuits with carbon nanotube units; and discovery on the molecular structure of DNA maintenance enzymes with AFM

Developments in nanotechnology in the 1990s produced developing electronic gadgets from single molecules a likelihood. Cees Dekker recounts how his staff designed a place-temperature transistor based upon one carbon nanotube.

2004, discovery of latest physics in translocation of DNA via nanopores; to start with experimental review of ions conduction in cees dekker nanofluidic channels; very first electrochemistry with individual one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; to start with electrical docking of microtubules on kinesin-coated nanostructures; initially biophysics characterization on the mechanical Qualities of double-stranded RNA; and to start with solitary-molecule analyze of DNA translocation by a restriction-modification enzyme.

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